Structure of the Mammalian Ribosome-Sec61 Complex to 3.4 Resolution
نویسندگان
چکیده
Rebecca M. Voorhees,1,2,* Israel S. Fernández,1,2 Sjors H.W. Scheres,1 and Ramanujan S. Hegde1,* 1MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK 2Co-first authors *Correspondence: [email protected] (R.M.V.), [email protected] (R.S.H.) http://dx.doi.org/10.1016/j.cell.2014.05.024 This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
منابع مشابه
Structure of the Mammalian Ribosome-Sec61 Complex to 3.4 Å Resolution
Cotranslational protein translocation is a universally conserved process for secretory and membrane protein biosynthesis. Nascent polypeptides emerging from a translating ribosome are either transported across or inserted into the membrane via the ribosome-bound Sec61 channel. Here, we report structures of a mammalian ribosome-Sec61 complex in both idle and translating states, determined to 3.4...
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